An Integrated Computational Approach for Plant-Based Protein Tyrosine Phosphatase Non-Receptor Type 1 Inhibitors
نویسندگان
چکیده
منابع مشابه
An Integrated Computational Approach for Plant-Based Protein Tyrosine Phosphatase Non-Receptor Type 1 Inhibitors
BACKGROUND Protein tyrosine phosphatase non-receptor type 1 is a therapeutic target for the type 2 diabetes mellitus. According to the International Diabetes Federation 2015 report, one out of 11 adults suffers from diabetes mellitus globally. OBJECTIVE Current anti-diabetic drugs can cause life-threatening side-effects. The present study proposes a pipeline for the development of effective a...
متن کاملUCSD MOLECULE PAGES Tyrosine-protein phosphatase non-receptor type 2
TC-PTP is a ubiquitous non-receptor type protein tyrosine phosphatase that shows highest expression in hematopoietic tissues. It regulates many signal transduction pathways in hematopoietic as well as non-hematopoietic cells. TCPTP has two splice variants, an endoplasmic reticulum-localized TC48, and predominantly nuclear TC45. Upon various stress conditions and insulin stimuli, TC45 comes out ...
متن کاملPTPRA ( protein tyrosine phosphatase , receptor type , A )
Review on PTPRA, with data on DNA/RNA expression, on the protein encoded, and the functional importance of the gene.
متن کاملNovel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies.
The Atlas of Diabetes reports 415 million diabetics in the world, a number that has surpassed in half the expected time the twenty year projection. Type 2 diabetes is the most frequent form of the disease; it is characterized by a defect in the secretion of insulin and a resistance in its target organs. In the search for new antidiabetic drugs, one of the principal strategies consists in promot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Computer-Aided Drug Design
سال: 2017
ISSN: 1573-4099
DOI: 10.2174/1573409913666170406145607